Biology of Sport
pISSN 0860-021X    eISSN 2083-1862
Archival Issues
Volume 33, 2016
Volume 32, 2015
Volume 31, 2014
Volume 30, 2013
Volume 29, 2012
Volume 28, 2011
Volume 27, 2010
Volume 26, 2009
Volume 25, 2008
Volume 24, 2007
Volume 23, 2006
Volume 22, 2005
Volume 21, 2004
Volume 20, 2003
Archival Issues 1984-1998
Search
Newsletter
Information for Authors
Special Information
 » 
Journal Abstract
 
Increased extracellular dopamine and 5-hydroxytryptamine levels contribute to enhanced subthalamic nucleus neural activity during exhausting exercise
Yanru Hu, Xiaoli Liu, Decai Qiao
Biol Sport 2015; 32(3):187-192
ICID: 1150299
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
 
The purpose of the study was to explore the mechanism underlying the enhanced subthalamic nucleus (STN) neural activity during exhausting exercise from the perspective of monoamine neurotransmitters and changes of their corresponding receptors. Rats were randomly divided into microdialysis and immunohistochemistry study groups. For microdialysis study, extracellular fluid of the STN was continuously collected with a microdialysis probe before, during and 90 min after one bout of exhausting exercise. Dopamine (DA) and 5-hydroxytryptamine (5-HT) levels were subsequently detected with high-performance liquid chromatography (HPLC). For immunohistochemistry study, the expression of DRD2 and HT2C receptors in the STN, before, immediately after and 90 min after exhaustion was detected through immunohistochemistry technique. Microdialysis study results showed that the extracellular DA and 5-HT neurotransmitters increased significantly throughout the procedure of exhausting exercise and the recovery period (P<0.05 or P<0.01). Immunohistochemistry study results showed that the expression levels of DRD2 and HT2C in the rat STN immediately after exhausting exercise and at the time point of 90 min after exhaustion were both higher than those of the rest condition, but the difference was not significant (P>0.05). Our results suggest that the increased extracellular DA and 5-HT in the STN might be one important factor leading to the enhanced STN neural activity and the development of fatigue during exhausting exercise. This study may essentially offer useful evidence for better understanding of the mechanism of the central type of exercise-induced fatigue.

ICID 1150299

DOI 10.5604/20831862.1150299
 
FULL TEXT 1252 KB


Related articles
  • in IndexCopernicus™
         monoamine neurotransmitters [0 related records]
         immunohistochemistry [0 related records]
         microdialysis [0 related records]
         Subthalamic nucleus (STN) [0 related records]
         central fatigue [0 related records]


  •  

    Copyright © Biology of Sport  2017
    Page created by Index Copernicus Ltd. All Rights reserved.