Biology of Sport
pISSN 0860-021X    eISSN 2083-1862
Archival Issues
Volume 34, 2017
Volume 33, 2016
Volume 32, 2015
Volume 31, 2014
Volume 30, 2013
Volume 29, 2012
Volume 28, 2011
Volume 27, 2010
Volume 26, 2009
Volume 25, 2008
Volume 24, 2007
Volume 23, 2006
Volume 22, 2005
Volume 21, 2004
Volume 20, 2003
Archival Issues 1984-1998
Search
Newsletter
Information for Authors
Special Information
 » 
Journal Abstract
 
Long-term treadmill exercise improves spatial memory of male appswe/ps1de9 mice by regulation of BDNF expression and microglia activation
Jingyu Xiong, Shicheng Li, Yaxin Sun, Xiaoshuang Zhang, Zhizhang Dong, Ping Zhong, Xuerong Sun
Biol Sport 2015; 32(4):295-300
ICID: 1163692
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
 
Increasing evidence suggests that physical activity could delay or attenuate the symptoms of Alzheimer’s disease (AD). But the underlying mechanisms are still not fully understood. To investigate the effect of long-term treadmill exercise on the spatial memory of AD mice and the possible role of β-amyloid, brain-derived neurotrophic factor (BDNF) and microglia in the effect, male APPswe/PS1dE9 AD mice aged 4 months were subjected to treadmill exercise for 5 months with 6 sessions per week and gradually increased load. A Morris water maze was used to evaluate the spatial memory. Expression levels of β-amyloid, BDNF and Iba-1 (a microglia marker) in brain tissue were detected by immunohistochemistry. Sedentary AD mice and wildtype C57BL/6J mice served as controls. The results showed that 5-month treadmill exercise significantly decreased the escape latencies (P<0.01 on the 4th day) and improved the spatial memory of the AD mice in the water maze test. Meanwhile, treadmill exercise significantly increased the number of BDNF-positive cells and decreased the ratios of activated microglia in both the cerebral cortex and the hippocampus. However, treadmill exercise did not significantly alleviate the accumulation of β-amyloid in either the cerebral cortex or the hippocampus of the AD mice (P>0.05). The study suggested that long-term treadmill exercise could improve the spatial memory of the male APPswe/PS1dE9 AD mice. The increase in BDNF-positive cells and decrease in activated microglia might underpin the beneficial effect.

ICID 1163692

DOI 10.5604/20831862.1163692
 
FULL TEXT 1296 KB


Related articles
  • in IndexCopernicus™
         Microglia [39 related records]
         Brain-Derived Neurotrophic Factor [11 related records]
         mice [0 related records]
         Exercise [0 related records]
         Alzheimer’s Disease [53 related records]


  •  

    Copyright © Biology of Sport  2017
    Page created by Index Copernicus Ltd. All Rights reserved.