Biology of Sport
pISSN 0860-021X    eISSN 2083-1862
Archival Issues
Volume 34, 2017
Volume 33, 2016
Volume 32, 2015
Volume 31, 2014
Volume 30, 2013
Volume 29, 2012
Volume 28, 2011
Volume 27, 2010
Volume 26, 2009
Volume 25, 2008
Volume 24, 2007
Volume 23, 2006
Volume 22, 2005
Volume 21, 2004
Volume 20, 2003
Archival Issues 1984-1998
Search
Newsletter
Information for Authors
Special Information
 » 
Journal Abstract
 
Are genes encoding proteoglycans really associated with the risk of anterior cruciate ligament rupture?
Paweł Cięszczyk, Kyle Willard, Piotr Gronek, Piotr Zmijewski, Grzegorz Trybek, Joanna Gronek, Magdalena Weber-Rajek, Petr Stastny, Miroslav Petr, Ewelina Lulińska-Kuklik, Krzysztof Ficek, Egle Kemeryte-Riaubiene, Ewelina Maculewicz, Alison September
Biol Sport 2017; 34(2):97-103
ICID: 1226520
Article type: Original article
IC™ Value: 10.00
Abstract provided by Publisher
 
Proteoglycans are considered integral structural components of tendon and ligament and have been implicated in the resistance of compressive forces, collagen fibrillogenesis, matrix remodelling and cell signalling. Several sequence variants within genes encoding proteoglycans were recently implicated in modulating anterior cruciate ligament ruptures (ACLR). This study aimed to test the previously implicated variants in proteoglycan and vascular epithelial growth factor encoding genes with risk of ACLR in a population from Poland. A case control genetic association study was conducted using DNA samples from 143 healthy participants without a history of ACL injuries (99 male and 44 females) (CON group) and 229 surgically diagnosed ACLR participants (158 males and 71 females). All samples were genotyped for the ACAN: rs1516797, BGN: rs1042103, rs1126499, DCN: rs516115 and VEGFA: rs699947 variants. Main findings included the (i) ACAN rs1516797 G/T genotype which was underrepresented in the CON group (CON: 36%, n=52, ACLR: 49%, n=112, p=0.017, OR=1.68, 95% CI 1.09 to 2.57) when all participants were investigated and (ii) the BGN rs1042103 A allele was significantly under-represented in the male CON group compared to the male ACLR group (CON: 39%, n=78, ACLR: 49%, n=156, p=0.029, OR=1.5, 95% CI 1.05 to 2.15). Furthermore, BGN inferred haplotypes were highlighted with altered ACLR susceptibility. Although the study implicated the ACAN and BGN genes (combination of genotype, allele and haplotype) in modulating ACLR susceptibility, several differences were noted with previous published findings.

ICID 1226520

DOI 10.5114/biolsport.2017.64582
 
FULL TEXT 289 KB


Related articles
  • in IndexCopernicus™
         Proteoglycans [73 related records]
         Biglycan [0 related records]
         Decorin [0 related records]
         aggrecan [0 related records]
         Vascular Endothelial Growth Factor A [646 related records]
         Anterior Cruciate Ligament [27 related records]
         Genetic Association Study [0 related records]
         Haplotypes [488 related records]


  •  

    Copyright © Biology of Sport  2017
    Page created by Index Copernicus Ltd. All Rights reserved.