Biology of Sport
pISSN 0860-021X    eISSN 2083-1862
Archival Issues
Volume 33, 2016
Volume 32, 2015
Volume 31, 2014
Volume 30, 2013
Volume 29, 2012
Volume 28, 2011
Volume 27, 2010
Volume 26, 2009
Volume 25, 2008
Volume 24, 2007
Volume 23, 2006
Volume 22, 2005
Volume 21, 2004
Volume 20, 2003
Archival Issues 1984-1998
Information for Authors
Special Information
Journal Abstract
GSTP1, GSTM1, and GSTT1 polymorphisms in Tibetan mountaineers
H Yan, X Sun, W Den, X Fan, T Liu
Biol Sport 2006; 23(3):303-311
ICID: 890843
Article type: Original article
IC™ Value: 9.29
Abstract provided by Publisher
Exposure to high altitude can increase the level of reactive oxygen species (ROS) in human beings. Physical exercises or working can exacerbate the effects of high altitude and further cause free radical mediated oxidative tissue injury. The glutathione S-transferases (GSTs) can scavenge ROS. Variant genotypes of GSTs lead to the inactive or decreased form of the enzymes. We hypothesized that the polymorphisms within these genes may explain the interindividual variation in response to high altitude hypoxia. We have evaluated the polymorphisms of GSTP1, GSTM1 and GSTT1 genes in 86 excellent Tibetan mountaineers and in 90 sea-level Han Chinese were used as the control group. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphism in exon 5 (Ile105Val). Both GSTM1 and GSTT1 genotypes were determined by multiplex PCR. The result showed that GSTM1 null genotype was found in 60.5% of Tibetan mountaineers and in 54.4% of sea-level Han Chinese. No difference was observed in the frequency of polymorphic genotype for GSTM1 (×2=0.65, p=0.26), (OR=0.78; 95% CI:0.43-1.42). The frequency of GSTT1 null genotype was 36.1% among Tibetan mountaineers, 51.1% among Han Chinese. The difference was statistically significant (×2=4.06, p=0.031), (OR=1.86; 95% CI: 1.01-3.39). The proportion of GSTP1-105 mutant homozygote was significantly lower in the Tibetan mountaineers than in the control subjects (26.7% vs 44.4%) (×2=5.99, p=0.011).The OR for GSTP1-105 mutant genotype versus wild genotype was 2.19 (95% CI=1.16-4.13). These results suggest that GSTT1 and GSTP1-105 genotypes may be associated with the interindividual variation in response to high altitude hypoxia, and may be two new markers in gene screening for human adaptation to high altitude.

ICID 890843

Related articles
  • in IndexCopernicus™
         Reactive Oxygen Species [329 related records]
         GSTP1 [0 related records]
         GSTT1 [3 related records]
         GSTM1 [3 related records]
         high altitude [1 related records]


    Copyright © Biology of Sport  2017
    Page created by Index Copernicus Ltd. All Rights reserved.