Medial collateral ligament repair following complete ligament transection: an experimental study in rabbits E Carmeli, Y Beer, N Halperin, R Coleman, D Robinson, T Brosh, Z Nevo Biol Sport 2004; 21(4):379-391 ICID: 891743
Article type: Original article
IC™ Value: 10.26
Abstract provided by Publisher
The purpose of this study was to evaluate the repair processes of the medial collateral (MCL), lateral collateral (LCL), anterior cruciate (ACL) and posterior cruciate (PCL) ligaments after complete dislocation by arthrotomy, and after disconnection. Forty eight mature young male white New Zealand rabbits. All four ligaments were reconnected using non-absorbable sutures, without limb immobilization. The contralateral knees served as internal controls. The effectiveness of Diclofenac (Voltaren, an NSAID), hyaluronic acid, and hyaluronic acid combined with collagenase in the healing processes was examined. 12 non-operated rabbits (control group) received intraarticular injections of 1 ml 0.9% saline 3 per week for 3 weeks; 12 rabbits received intramuscular (Glutei) injections of Diclofenac sodium 1% (1ml/1kg BW) 3 per week for 3 weeks; 12 rabbits received intraarticular injections with 1 ml hyaluronic acid alone; 12 rabbits received intraarticular injections of hyaluronic acid and collagenase. Biomechanical and histological examinations of the joints were performed. The results indicated that healing of ACL and PCL was not achieved in any group. A favorable response to Diclofenac treatment was noticed in MCL as determined by both histology and biomechanical testing. In conclusions, Diclofenac administered by injections may offer some clinical benefits following major knee operations or injury.