Biology of Sport
pISSN 0860-021X    eISSN 2083-1862
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Journal Abstract
 
Differences in collagen gene expression in male and female anterior cruciate ligament injured athletes
X Liu, T Tingle, DM Lintner, WR Lowe, QJ Zhai, ZP Luo
Biol Sport 2009; 26(3):255-261
ICID: 894790
Article type: Original article
IC™ Value: 9.80
Abstract provided by Publisher
 
Anterior Cruciate Ligament (ACL) injuries occur two to eight times more frequently in women than men. However, it remains unclear whether gender differences exist in ACL at the molecular level. Using reverse transcript polymerase chain reaction (RT-PCR) with histological analysis, the gene expressions of collagen types I and III of fibroblasts from ACLs of 17 male and 17 female athletes with acute ACL tears were studied. Female athletes were found to have a significantly lower gene expression of collagen I. No significant difference was found in type III collagen gene expression between male and female athletes. This finding may help us to explain the higher incidence of ACL injury in female athletes from the molecular perspective.

ICID 894790

DOI 10.5604/20831862.894790
 
FULL TEXT 173 KB


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         anterior cruciate ligament (ACL) [1 related records]
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         RT-PCR [17 related records]


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