Biology of Sport
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Journal Abstract
 
POTENTIAL ROLE OF PHOSPHORYLATION OF p70S6K IN DIFFERENT EXTENTS OF MUSCLE ATROPHY ACCORDING TO TYPE OF SKELETAL MUSCLE DURING ANKLE IMMOBILIZATION IN RAT
J-S You, H-U Lee, M-N Park, Y-S Lee
Biol Sport 2011; 28(2):123-128
ICID: 946498
Article type: Original article
IC™ Value: 10.06
Abstract provided by Publisher
 
Akt and p70 ribosomal S6 kinase (p70s6k) play a critical role in regulation of skeletal muscle mass in response to a variety of mechanical stimuli. However, the regulation of these molecules under decreased muscle usage has rarely been investigated according to skeletal muscle types that affect the rate of disuse muscle atrophy. This study was conducted in rats to elucidate the responses of Akt and p70s6k phosphorylation to ankle immobilization in different types of plantar flexors and its association with the muscle atrophy rate in the muscles. The results revealed that the rate of muscle atrophy in response to ten days of ankle immobilization was significantly less in the plantaris (PL) and gastrocnemius, which could not be completely immobilized with the ankle fixation, than in the soleus (SOL) (P<0.05). In accordance with these findings, the decrease in phosphorylation of p70s6k (T389) that was observed in SOL (P<0.001) was not observed in PL, and its level even increased in fast-twitch white gastrocnemius (WG) (P<0.05). However, phosphorylation of Akt (S473) was lower in all three muscles in response to immobilization treatment. The Akt-independent phosphorylations of p70s6k in PL and WG were further confirmed by the decreased phosphorylation of Akt (T308) and GSK3α. These results suggest that the skeletal muscle type-specific different rates of muscle atrophy that occur during ankle immobilization may be mediated by p70s6k, which responds differently in the distinct types of skeletal muscle

ICID 946498

DOI 10.5604/946498
 
FULL TEXT 467 KB


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